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Alteration of serum cathepsins and glycosylated hemoglobin concentrations after aerobic and resistance training
in type 2 diabetic men
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Mohammad Derakhshan    , Abdolhossein Taheri Kalani , Fardin Fatahi |
| Department of Exercise Physiology, Ilam Branch, Islamic Azad University, Ilam, Iran , taherikalani@ilam-iau.ac.ir |
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Abstract: (154 Views) |
Background and aims: Adipokines have recently emerged as potential biomarkers for diabetes management. Given the presence of various cathepsins in adipose tissue, the identification of these enzymes in the context of obesity and diabetes has garnered significant attention. This study aimed to compare the alterations in serum cathepsin levels and glycosylated hemoglobin (HbA1c) following aerobic and resistance training in men diagnosed with type 2 diabetes.
Methods: In this quasi-experimental study, 29 men aged between 25 and 45 with type 2 diabetes were randomly assigned to three groups: aerobic training, resistance training, and a control group. The participants underwent aerobic training (at 55-75% of their maximum heart rate) or resistance training (at 55-75% of their one-repetition maximum) three times a week for 10 weeks. Serum levels of cathepsins K, L, and S, along with HbA1c percentages, were measured before and after the intervention.
Results: Both the aerobic and resistance training groups exhibited significant decreases in the serum levels of cathepsins K, L, and S, as well as HbA1c, in comparison to the control group (p<0.05). However, no notable differences were observed between the two training modalities.
Conclusion: The findings suggest that both aerobic and resistance training are equally effective in mitigating diabetes-related risks by reducing cathepsin levels and HbA1c concentrations.
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| Keywords: Cathepsins, HbA1c, Type 2 Diabetes Mellitus, Aerobic Exercise, Resistance Training |
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Full-Text [PDF 1251 kb]
(128 Downloads)
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Type of Study: Brief Report |
Subject:
Military Medicine
Received: 2023/12/4 | Accepted: 2024/06/6 | Published: 2024/08/3
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