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:: Volume 17, Issue 3 (Autumn 2015) ::
EBNESINA 2015, 17(3): 5-10 Back to browse issues page
The effect of immobilization and surgery stress on serum ghrelin level, body weight, and food consumption in male rats
P Zareian , A Mozafar, H Kargar Jahromi
Department of physiology, AJA University of Medical Science, Tehran, Iran , zareianj2011@yahoo.com
Abstract:   (2420 Views)

Background: In our daily life, we encounter with various types of stress. These stresses result to different autonomic, hormonal, and behavioral responses. One of the hormones that its secretion is affected by stress is called ghrelin. The aim of this study was to investigate the effect of immobilization and surgery stress on serum ghrelin level, food consumption, and body weight in male rats.

Materials and methods: Forty Sprague Dawley male rats (200-220 g weight) were used. The serum ghrelin level (via Elisa method), food consumption (with daily measurement), and changes in body weight (in seven days) were measured following the surgery and immobilization stress. Also, body weight was measured in the first and 7th day.

Results: Compared to the control group, immobilization stress caused a significant increase in the level of serum ghrelin (56.8±8.5 vs. 31.7±3.7 pg/ml (and food consumption (371.3 vs. 287±11 g). The increase of body weight was lower than the control group (2.3±1 vs. 12±2 g). It was interesting to note that the surgical stress had no significant effect on the serum ghrelin level, food consumption, and body weight.

Conclusion: In this work, only the stress of immobilization caused a significant change on the serum ghrelin level, food consumption, and body weight; so it seems that the effect of stress on these factors depends on the kind of stress.

Keywords: Physiological Stresses, Operative Surgical Procedures, Immobilization, Ghrelin, Body Weight
Full-Text [PDF 575 kb]   (655 Downloads)    
Type of Study: Original |
Received: 2015/02/5 | Accepted: 2016/01/14 | Published: 2016/01/27
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Zareian P, Mozafar A, Kargar Jahromi H. The effect of immobilization and surgery stress on serum ghrelin level, body weight, and food consumption in male rats. EBNESINA. 2015; 17 (3) :5-10
URL: http://ebnesina.ajaums.ac.ir/article-1-240-en.html


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Volume 17, Issue 3 (Autumn 2015) Back to browse issues page
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