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:: Volume 19, Issue 3 (Autumn 2017) ::
2017, 19(3): 4-12 Back to browse issues page
The effect of exercise training before and after exposure to breast cancer on Bax and Bcl-2 levels on myocardial tissue in female mice
Z Ebrahimpur , M Peeri , H Matin Homaee , P Farzanegi
Professor Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran , zeynab1155@yahoo.com
Abstract:   (149 Views)

Background: Breast cancer is the most common type of cancer among women. Also, the risk of mortality from cardiovascular diseases in these patients is more than other people. Aerobic exercise is effective in the prevention and treatment of cardiovascular diseases and breast cancer. This study was performed to investigate the effects of swimming exercise before and after of cancer on levels of Bax and Bcl-2 in female mice of myocardium.
Materials and methods: In this study, 56 BALB/c mice were randomly divided into two active and passive groups. The active group swam in the water pool before breast cancer for four weeks, three days per week and 30 minutes daily. Passive group did no exercise before cancer cell inoculation. Then, both groups were separately divided into four subgroups: a) continue to exercise, b) rest, c) doxorubicin, and d) exercise/doxorubicin. Finally, Bax and Bcl-2 levels (as apoptotic markers) in myocardial tissue were measured.
Results: The Results showed that level of Bcl-2 and Bax in myocardial tissue respectively increased and decreased significantly in the group that had aerobic swimming exercise before and after breast cancer in comparison to the group that did not exercise, .
Conclusion: Aerobic swimming exercises before and after the breast cancer is effective on the level of Bax and Bcl-2 in myocardial tissue in mice with breast cancer. Therefore, regular swimming aerobic exercise may increase myocardial cell survival in breast cancer patients.

 

Keywords: Bax protein mouse, bcl-2 Gene, Breast Cancer, Swimming, Myocardium
Full-Text [PDF 577 kb]   (74 Downloads)    
Type of Study: Research | Subject: Special
Received: 2016/11/12 | Accepted: 2017/10/11 | Published: 2017/10/11
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Ebrahimpur Z, peeri M, Matin Homaee H, farzanegi P. The effect of exercise training before and after exposure to breast cancer on Bax and Bcl-2 levels on myocardial tissue in female mice. EBNESINA- Journal of Medical. 2017; 19 (3) :4-12
URL: http://ebnesina.ajaums.ac.ir/article-1-466-en.html
Volume 19, Issue 3 (Autumn 2017) Back to browse issues page
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