[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 19, Number 3 (Autumn 2017) ::
2017, 19(3): 13-23 Back to browse issues page
The effect of exercise intervention on angiogenesis gene expression (inducing and inhibiting factors) following myocardial ischemia-reperfusion
Y Mehrialvar , AR Ramazani, A Gaeini, F Golab, R Gheiratmand
Associate professor , yaghoob.alvar@ut.ac.ir
Abstract:   (32 Views)

Background: Angiogenic process is vital to cure the injured parts of the heart. This study was conducted with the aim to investigate the effect of exercise intervention on the expression of inducing and inhibiting factors involved in the angiogenic and antiangiogenic properties following myocardial ischemia-reperfusion.
Materials and methods: In this study, 28 male Wistar rats (200-250 g) were randomly used in four groups: 1) sham; 2) ischemia; 3) exercise; and 4) exercise-ischemia. Myocardial Infarction (MI) was induced by descending coronary artery ligation for 30 minutes. Treadmill exercise program was performed for eight weeks, three days per week, and 40 minutes per day. The mice were anesthetized and the cardiac tissue was isolated 48 hours after the last training session and injections. Gene expression of VEGF, TSP-1, AKt, and Apelin was measured for heart tissue cells.
Results: The results showed that there is a significant difference between the four groups in the gene expression levels of VEGF, TSP-1, AKt, and Apelin (p=0.001). Bonferroni post-hoc test showed that the gene expression levels of VEGF, AKt, and Apelin increased significantly in the exercise-ischemia group compared to sham, ischemia, and exercise groups (p<0.05). In fact, exercises during ischemia intervention may lead to increase the gene expression of Apelin, VEGF, and AKt. However, exercise did not make this change itself (p>0.05). On the other hand, the results showed a significant decrease in gene expression level of TSP-1 in exercise-ischemia, ischemia, and exercise groups compared to the sham group (p<0.05).
Conclusion: Exercise following myocardial ischemia intervention tends to remove the negative factors and increase the positive factors of angiogenesis to make the tissue achieving the angiogenic balance.
 

Keywords: Ischemia-Reperfusion Injury, Angiogenesis Stimulators, Angiogenic Inhibitors, Apelin, TSP-1, Protein Kinase B
Full-Text [PDF 849 kb]   (11 Downloads)    
Type of Study: Research | Subject: Special
Received: 2017/06/5 | Accepted: 2017/10/12 | Published: 2017/10/12
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mehrialvar Y, Ramazani A, Gaeini A, Golab F, Gheiratmand R. The effect of exercise intervention on angiogenesis gene expression (inducing and inhibiting factors) following myocardial ischemia-reperfusion . EBNESINA- Journal of Medical. 2017; 19 (3) :13-23
URL: http://ebnesina.ajaums.ac.ir/article-1-539-en.html
Volume 19, Number 3 (Autumn 2017) Back to browse issues page
ابن سینا EBNESINA
Persian site map - English site map - Created in 0.057 seconds with 793 queries by yektaweb 3471