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:: Volume 22, Issue 4 (Winter 2021) ::
EBNESINA 2021, 22(4): 89-94 Back to browse issues page
The effect of eight weeks of daily normobaric hypoxia (60 minutes) on PGC­1α content of soleus muscle, insulin resistance, and fasting glucose in type 2 diabetic rats
SeyedAliAkbar FallahpourNooshabadi , Yaser Kazemzadeh , Ali Gorzi
Department of Exercise Physiology, Islamshahr Branch, Islamic Azad University, Islamshahr, Iran , yaser.kazemzadeh@yahoo.com
Abstract:   (132 Views)
Background: It has been observed that PGC-1α content decreases in type 2 diabetes. In addition, hypoxia has been introduced as a new therapeutic intervention in type 2 diabetes. Therefore, the aim of this study was to evaluate the effect of eight weeks of daily normobaric hypoxia (60 minutes) on PGC-1α content of soleus muscle, insulin resistance, and fasting glucose in type 2 diabetic rats.
Materials and methods: In this study, 24 male Wistar rats were divided into three groups: control, diabetic, and diabetic hypoxia. In diabetic groups, induction of diabetes was performed by HFD-STZ method. The plan consisted of eight weeks, five sessions per week and 60 minutes of exposure to normobaric hypoxia with 14.4% oxygen in the diabetic hypoxia group in each session. At the end, tissue and blood samples were extracted for analysis. Statistical analysis was performed by one-way analysis of variance.
Results: The results of analysis of variance showed a significant difference in all three variables (p=0.0001). The results of post hoc test indicated a significant difference in PGC-1α between control and diabetic groups (p=0.0001), between control and diabetic hypoxia (p=0.0001),  and between diabetic and diabetic hypoxia (p=0.009). Also, the post hoc test among three groups showed a significant difference (p=0.0001) in variables of fasting glucose and resistance to insulin.
Conclusion: Due to the effect of normobaric hypoxia on the increase of PGC-1α, the decrease of fasting glucose, and resistance to insulin, normobaric hypoxia can be used as a new treatment strategy in type 2 diabetes.
Keywords: Type 2 Diabetes, Blood Glucose, Insulin Resistance, Hypoxia, PGC-1-alpha Protein
Full-Text [PDF 729 kb]   (35 Downloads)    
Type of Study: Research | Subject: General
Received: 2020/10/18 | Accepted: 2021/01/9 | Published: 2021/03/2
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FallahpourNooshabadi S, Kazemzadeh Y, Gorzi A. The effect of eight weeks of daily normobaric hypoxia (60 minutes) on PGC­1α content of soleus muscle, insulin resistance, and fasting glucose in type 2 diabetic rats. EBNESINA. 2021; 22 (4) :89-94
URL: http://ebnesina.ajaums.ac.ir/article-1-909-en.html


Volume 22, Issue 4 (Winter 2021) Back to browse issues page
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