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Showing 2 results for Mahmoud Alilou
Majid Mahmoud Alilou, Soheila Parvaz, Zeinab Khanjani, Touraj Hashemi, Volume 21, Issue 1 (Spring 2019)
Abstract
Background: A clinical tool for detecting early signs of cognitive degeneracy in the elderly population can help clinicians to identify dementia in the early stages. This research was aimed to validate the Persian version of Addenbrooke’s Cognitive Examination-III (ACE-III) in patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) in a group of Iranian population.
Materials and methods: A total of 135 subjects (AD= 30, MCI=30 and 75 normal control) that met inclusion criteria participated in the study. All patients were diagnosed by neurologist using neuroimaging tools and routine clinical examination. Data were analyzed using receiver operating characteristic (ROC) curves, Pearson’s correlation analysis and multivariate analysis of variance (MANOVA).
Results: ACE-III at cut-off point of 75 showed 99% sensitivity and 95% specificity in discriminating AD from the normal group and at cut-off point of 82 showed 92% sensitivity and 90% specificity in discriminating MCI from normal controls. Test-retest reliability showed a correlation of 0.94 for both AD and MCI. Internal consistency using Cronbach’s alpha was 0.97. A significant difference was seen between AD and control group on total score and all ACE-III components (attention, memory, language, verbal fluency and visuospatial function). MCI group was differed from control group on memory and visiouspatial components.
Conclusion: The Persian version of ACE-III is a reliable and useful cognitive screening tool for diagnosis of dementia and has a high specificity.
Aisan Farzi, Majid Mahmoud Alilou, Khalil Esmailpour, Volume 26, Issue 3 (Autumn 2024)
Abstract
Background and aims: Self-injury and substance abuse in people with borderline personality disorder can lead to serious harm to themselves and those around them. Therefore, the purpose of this study was to investigate the effectiveness of mindfulness and emotion regulation therapy based on dialectical behavior therapy on substance abuse and self-injury in people with borderline personality disorder (BPD).
Methods: This research was conducted using a single-case experimental design (SCED) of the multiple baseline type, consisting of eight one-hour sessions for three patients, followed by a one-month follow-up period. The statistical population included patients diagnosed with PBD. Three individuals were selected based on their voluntary participation and adherence to the research criteria, utilizing targeted and available sampling methods. Inclusion was based on a psychiatrist's diagnosis and a structured clinical interview. They received dialectical behavior therapy based on emotion regulation and mindfulness for eight sessions. Data were collected using the Risky Behaviors Questionnaire by Mohammadkhani and the Personality Assessment Inventory Borderline Features Scale (PAI-BFS).
Results: Data analysis, presented through graphs and tables for SCED, indicated that mindfulness and emotion regulation interventions based on dialectical behavior therapy resulted in significant changes. The effect sizes for the first subject in the variables of self-harm and substance abuse were 4.526 and 2.260, respectively; for the second subject, they were 6.253 and 6.772; and for the third subject, they were 3.651 and 6.134.
Conclusion: This treatment method has led to statistically significant improvements in the symptoms of substance abuse and self-harm among patients with BPD.
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