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:: Volume 14, Issue 1 And 2 (Spring & summer 2011) ::
EBNESINA 2011, 14(1 And 2): 10-16 Back to browse issues page
The preventative role of sesame oil on phlebitis induced by anti-neoplastic agents
N Nekozad , T Ashktorab Dr, F Mojab Dr, H Alavi, P Azadeh Dr
Abstract:   (13264 Views)
Background: Phlebitis is an inflammatory response to intravenously injected chemotherapy drugs and the reported incidences about 70% among colorectal cancer patients. The purpose of this study was to determine the effect of external use of Sesame Oil (SO) in prevention of chemotherapy-induced phlebitis.
Materials and methods: This randomized controlled clinical trial was performed on 60 patients with colon or rectum cancer, who randomly divided in two equal, control & intervention groups. This protocol was used 10 drops of SO every 12 hours, two times a day, from the first day of chemotherapy up to the four tenth day, whereas control group received nothing. Data tools included a bipartite questionnaire (demographic Q, clinical Q & Infusion Therapy scale) for measurement of phlebitis.
Results: The incidence of phlebitis in intervention group were significantly lower than that in control group (p<0.05). Kaplan–Meier survival analysis showed that the median survival was Less than4 days in the intervention and 8 days more in the control. In addition, there was statistically significant difference between grade and incidence of chemotherapy-induced phlebitis with SO and control group (p<0.05).
Conclusion: This study shows that external use of SO is effective and well tolerated for prophylaxis from chemotherapy- induced phlebitis. Therefore, it can be suggest as a selected Prevention method for reducing the complication.
Keywords: Sesame Oil, Prophylaxis, Phlebitis, Chemotherapy
Full-Text [PDF 196 kb]   (1766 Downloads)    
Type of Study: Research | Subject: General
Received: 2012/05/23 | Accepted: 2014/06/3 | Published: 2014/06/3
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Nekozad N, Ashktorab T, Mojab F, Alavi H, Azadeh P. The preventative role of sesame oil on phlebitis induced by anti-neoplastic agents. EBNESINA. 2011; 14 (1 and 2) :10-16
URL: http://ebnesina.ajaums.ac.ir/article-1-123-en.html


Volume 14, Issue 1 And 2 (Spring & summer 2011) Back to browse issues page
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