Background: Addiction is a complex disease, and today we are witnessing the arrival of the new stimulant drugs that are highly addictive and harmful to the nervous system and other human organs. Therefore this study is conducted to determine the effectiveness of couple therapy with the imago therapy approach in reducing the symptoms related to drug abuse and impulse control in patients addicted to methamphetamine (Crystal). Materials and methods: Totally, 30 methamphetamine addicted men were voluntarily selected and randomly assigned into two groups of 15 persons. SCID-CV interview, questionnaire of Maudsley addiction profile (MAP) and the Barratt Impulsiveness questionnaire were used to determine the person's drug abuse, the psycho-physiological symptoms associated with drug use and evaluation of impulsivity in three stages of pre-test, post-test and follow-up. Results: Comparison of post-test grades in both groups of experimental and control showed that there was a significant difference in the level of 0.01 between the two groups in terms of the dependent variables of the symptoms associated with abuse and impulse control. In other words, after the intervention of imago therapy in the experimental group, both the dependent variable showed a significant decrease. In the follow-up stage, scores in both the dependent variable showed some increase, although retained the significant differences with the control group. Conclusion: The findings of this study showed that generally the intervention of Imago Relationship Therapy could obtain better condition in both the dependent variable of patient.