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:: Volume 20, Issue 3 (Autumn 2018) ::
EBNESINA 2018, 20(3): 4-11 Back to browse issues page
The effect of continues and high intensity training on gene expression of cTnT and cTnT in heart tissue of male rats
Forogh Foladi, Mohammad reza Asad, Mohammad Fashi
Payame Noor University, Karaj , forogh_sh007@yahoo.com
Abstract:   (2080 Views)

Background: Cardiac troponin I and T (cTnI and cTnC) are regulatory proteins that encounter in myocardial contraction and are specific sensitive markers of cardiac cell necrosis. The aim of this study was to determine the effect of continues and high-intensity training (HIIT) on cTnT and cTnI gene expression in the cardiac tissue of male Wistar rats.
Materials and methods: In this experimental study, 18 Wistar rats with body weight average 263±12 gr were studied for eight weeks in three groups: control, continuous endurance training (CET) (five sessions per week at 70% max speed) and HIIT (three sessions per week at intensity of 90 to 110% max speed) under standard conditions. Expression of cTnT and cTnI genes were assessed by Real time-PCR and the quantification of expression levels was analyzed by the 2-ΔΔct formula and one-way ANOVA statistical method with the significance level of p≤0.05. 
Results: There were significant differences in the mean expression of cTnT between control group and both CET (p=0.001) and HIT (p=0.001) groups. The expression of cTnT was higher in HIIT than endurance training group (p=0.021). The results also showed that there was no significant difference in the mean of cTnI expression between different groups (p=0.523).
Conclusion: According to the findings, it seems that eight weeks of HIIT and CET can decrease the expression of cTnT which could be a result of reduction of hemodynamic and physiological pressures on the heart. These changes may be accompanied by reduction of heart damage.


Keywords: High-Intensity Interval Training, Gene Expressions, Exercise, Cardiac Troponin
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Type of Study: Original |
Received: 2017/04/18 | Published: 2018/10/15
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Foladi F, Asad M R, Fashi M. The effect of continues and high intensity training on gene expression of cTnT and cTnT in heart tissue of male rats. EBNESINA. 2018; 20 (3) :4-11
URL: http://ebnesina.ajaums.ac.ir/article-1-525-en.html

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