[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Ethics::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Index






     
 
..
:: Volume 21, Issue 1 (Spring 2019) ::
EBNESINA 2019, 21(1): 4-12 Back to browse issues page
Evaluation of the expression levels of pulmonary HSP70 and HSP90 in response to taper in hypoxic conditions
Mehdi Yadegari * , Shadmehr Mirdar , Gholamreza Hamidian , Hossein Berenjeian Tabrizi
university of mazandaran , mehdi.sport313@yahoo.com
Abstract:   (2841 Views)
Background: Despite the recognition of reduced workload in exercise as a model to increase exercise performance in normal conditions, there is no information on the effect of this training pattern on internal organs in hypoxic conditions. The purpose of this study was to investigate the response of HSP70 and HSP90 proteins to taper in hypoxia.
Materials and methods: The samples were twenty-four healthy male Wistar rats (8 control and 16 experimental rats) with no history of disease (four-weeks old, 72±9 gr weight). The experimental group were participated in an interval training program for six weeks, and then remained in hypoxic conditions for three weeks. Half of the experimental samples performed taper technique during exposure to the hypoxic environment. At the end of experimental period, the lung tissues of all samples were removed and the expression level of HSP70 and HSP90 proteins were evaluated. One-way ANOVA method was used for data analysis and p≤0.05 was considered as significant.
Results: The expression levels of HSP70 and HSP90 were significantly increased in the hypoxia group in contrast to the control group (p≤0.05).In the hypoxia-taper group, also, the expression of HSP70 and HSP90 was decreased significantly compared to the hypoxia group (p≤0.05).
Conclusion:  The results show that hypoxia can causes biological stress in lung tissue, leading to lung protective response by increasing the expression of heat-shock proteins, and performing of interval exercise training with less intense in hypoxic conditions may help to maintain lung hemostasis.
Keywords: Hypoxia, Heat-Shock Proteins, Lung
Full-Text [PDF 1096 kb]   (795 Downloads)    
Type of Study: Original | Subject: Aerospace Medicine
Received: 2018/07/13 | Accepted: 2019/03/16 | Published: 2019/03/16
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Yadegari M, mirdar S, hamidian G, Berenjeian Tabrizi H. Evaluation of the expression levels of pulmonary HSP70 and HSP90 in response to taper in hypoxic conditions. EBNESINA 2019; 21 (1) :4-12
URL: http://ebnesina.ajaums.ac.ir/article-1-688-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 21, Issue 1 (Spring 2019) Back to browse issues page
ابن سینا EBNESINA
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4645