Faculty of Aerospace and Subaquatic Medicine, Aerospace Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran , z.jahan14@gmail.com
Abstract: (1699 Views)
Physiological properties of adaptation to chronic hypoxia can help the high-altitude natives to overcome oxygen limitations. The protective effects of high altitudes have also been confirmed in experimental studies using the hypobaric chamber. Many factors have been introduced about molecular mechanisms of the protective effects of chronic hypoxia. Studies in the past decades and recent genomic studies have suggested a genetic basis for these physiological adaptations in these areas. It is also known that patterns of genetic variations are different among major populations of high altitudes. This article is a review of the physiological adaptations to chronic hypoxia and its molecular and genetic mechanisms.
Khademi A, Jahanbakhsh Z, Yousefpour M, Karami Juyani A. Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives
Molecular and genetic mechanisms
of physiological adaptations
in high- altitude natives. EBNESINA 2019; 21 (4) :59-73 URL: http://ebnesina.ajaums.ac.ir/article-1-695-en.html