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:: Volume 21, Issue 4 (Winter 2020) ::
EBNESINA 2020, 21(4): 59-73 Back to browse issues page
Molecular and genetic mechanisms of physiological adaptations in high- altitude natives Molecular and genetic mechanisms of physiological adaptations in high- altitude natives
Abolfazl Khademi, Zahra Jahanbakhsh , Mitra Yousefpour, Afsaneh Karami Juyani
Faculty of Aerospace and Subaquatic Medicine, Aerospace Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran , z.jahan14@gmail.com
Abstract:   (747 Views)
Physiological properties of adaptation to chronic hypoxia can help the high-altitude natives to overcome oxygen limitations. The protective effects of high altitudes have also been confirmed in experimental studies using the hypobaric chamber. Many factors have been introduced about molecular mechanisms of the protective effects of chronic hypoxia. Studies in the past decades and recent genomic studies have suggested a genetic basis for these physiological adaptations in these areas. It is also known that patterns of genetic variations are different among major populations of high altitudes. This article is a review of the physiological adaptations to chronic hypoxia and its molecular and genetic mechanisms.
 
Keywords: Physiological Adaptation, Altitude Hypoxia, Genetic Variation
Full-Text [PDF 993 kb]   (167 Downloads)    
Type of Study: case report | Subject: Aerospace Medicine
Received: 2018/07/29 | Accepted: 2020/09/16 | Published: 2019/12/31
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Khademi A, Jahanbakhsh Z, Yousefpour M, Karami Juyani A. Molecular and genetic mechanisms of physiological adaptations in high- altitude natives Molecular and genetic mechanisms of physiological adaptations in high- altitude natives. EBNESINA. 2020; 21 (4) :59-73
URL: http://ebnesina.ajaums.ac.ir/article-1-695-en.html


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Volume 21, Issue 4 (Winter 2020) Back to browse issues page
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