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Determination of anti sperm antibody before and after varicocelectomy
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J Samadi   , SK Madaen , K Alizadeh , N Bidi |
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Abstract: (11658 Views) |
Introduction: Varicocel is known as one of the most common causes for
male infertility which occurs by means of different mechanisms. In
particular immunological reasons such as anti sperm antibody
(ASA) may have role such infertility. Although varicocelectomy is
identified as a risk factor producing ASA , its role is not fully
understood , while the impact of some other surgeries including
vasectomy, orchiopexy and testis biopsy and infection on the
production of ASA have already been well recognized.
Materials and methods :Upon clinical examination, 65. Varicocel patients,
whose were candidate for varicocelectomy surgery, were selected
.A prospective study for an assessment of ASA level in semen and
serum pre and post surgery was conducted. The level of ASA was
measured by direct and indirect sperm-MAR-test. Over 15% ASA
level was considered as positive result.
Results: 60 patients with the mean age of 24(18-33) completed the
study. The semen analysis after surgery showed recovery regarding
all three parameters including sperm count, motility and
morphology, where changes in count and motility revealed
significant (p<0.05) differences. 29 % of patients before surgery
showed positive level of ASA(20-40%) , whose ASA level 3-month
after surgery yielded 53 %, and serum level of ASA before and after
surgery displayed significant (P=O.03l) differences. In semen,
however, the level of ASA did not show any differences (p=0.772)
.After surgery, semen parameters were compared within ASA
positive and negative patients and significant (p= 0.035) differences
were observed in terms of motility. Within patients with negative
ASA before surgery, 48 patients showed ASA level about 5-15%
with no effect on semen parameters.
Conclusion: Based on our findings, it can be concluded that
varicocelectomy may cause positive ASA levels in serum of patients
after surgery. However, in comparison with patient with negative
ASA after surgery, no fluctuation in the semen parameters can be
seen except reduction in motility. Since varicocelectomy displayed
no effect on semen ASA, thus varicocelectomy do not trigger
unfavorable effects, even if it initiates some increase in serum ASA. |
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| Keywords: Varicocel, Infertility, Antisperm antibody |
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Full-Text [PDF 362 kb]
(2263 Downloads)
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Type of Study: Original |
Received: 2012/03/7 | Accepted: 2014/06/3 | Published: 2014/06/3
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