TY - JOUR JF - ابهاد-نهاجا JO - EBNESINA VL - 21 IS - 4 PY - 2019 Y1 - 2019/12/01 TI - Molecular and genetic mechanisms of physiological adaptations in high- altitude nativesMolecular and genetic mechanisms of physiological adaptations in high- altitude natives TT - مکانیسم‌های مولکولی و ژنتیکیِ سازش‌های فیزیولوژیک در بومیان ساکن ارتفاعات بالا N2 - Physiological properties of adaptation to chronic hypoxia can help the high-altitude natives to overcome oxygen limitations. The protective effects of high altitudes have also been confirmed in experimental studies using the hypobaric chamber. Many factors have been introduced about molecular mechanisms of the protective effects of chronic hypoxia. Studies in the past decades and recent genomic studies have suggested a genetic basis for these physiological adaptations in these areas. It is also known that patterns of genetic variations are different among major populations of high altitudes. This article is a review of the physiological adaptations to chronic hypoxia and its molecular and genetic mechanisms. SP - 59 EP - 73 AU - Khademi, Abolfazl AU - Jahanbakhsh, Zahra AU - Yousefpour, Mitra AU - Karami Juyani, Afsaneh AD - Faculty of Aerospace and Subaquatic Medicine, Aerospace Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran KW - Physiological Adaptation KW - Altitude Hypoxia KW - Genetic Variation UR - http://ebnesina.ajaums.ac.ir/article-1-695-en.html DO - 10.22034/21.4.59 ER -