BBackground: The role of various herbs in reducing blood lipids and therefore risk of cardiovascular disease has been identified. The present study aimed to evaluate the effect of oral administration of powdered Fenugreek seed on the lipid profile. Materials and methods: This was a clinical trial study and conducted on 49 hyperlipidemia patients who were not use lipid-lowering medications. Patients were randomly divided into treatment (n=24) and control (n=25) groups. The treatment group received 5g/d of powdered of fenugreek seeds (as a package) with food for 8 weeks. BMI, total cholesterol, triglyceride, LDL, HDL, and FBS of patients were measured at the beginning and end of the study and finally data were compared using paired t-test. Results: The results indicated significant decrease (p<0.05) among treatment group in LDL, total cholesterol, triglyceride and FBS. There was no significant change was seen in HDL and BMI of patient in neither of the two groups. Conclusion: This study showed that consumption of fenugreek seeds powdered is effective in reducing of blood lipids in hyperlipidemia patients.