[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Ethics::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Index






     
 
..
:: Volume 18, Issue 1 (spring 2016) ::
EBNESINA 2016, 18(1): 4-10 Back to browse issues page
The effect of microgravity model (hind limb suspension) on the levels of testosterone and LH in rats
Sh Ghayumi , A Khoshvaghti * , A NurMohammadi
Aerospace medicine research center, Aerospace and subaquatic medicine faculty, AJA University of Medical Sciences, Tehran , anatomygray2009@gmail.com
Abstract:   (3908 Views)

Background: Weightlessness has different effects on human physiology. Microgravity causes major changes in various body systems in space; like changes in function of sexual system and the secretion of hormones. This study aimed to evaluate the effect of microgravity on the levels of testosterone and LH in rats.

Materials and methods: This experimental study was conducted on 14 adult male rats (race Wistar, the age of about three months, and their weight was approximately 250 grams) that were divided into two groups: control (kept in regular cages) and intervention (in hind limb Plexiglas cages). The dark-light cycle was scheduled 12 hours lightness (about 30 lux) followed by 12 hours darkness. For all rats, the levels of testosterone and LH were measured on days zero and 14. The gathered data were analyzed by SPSS software.

Results: At the baseline of the study, the mean value of testosterone was 1.038±0.08 in both groups and the mean value of LH was 5.15±0.62 and 5.40±0.24 in control and intervention groups, respectively (p>0.05). After 14 days, the level of testosterone was 1.04±0.07 in control group and 0.74±0.09 in intervention group (p<0.05). However, the level of LH was 5.43±0.28 in control group and 6.55±0.31 in intervention group (p<0.05).

Conclusion: In the intervention group, the level of testosterone decreased, while the level of LH increased. It indicates that microgravity only affected testis and pituitary function remained normal. According to these finding, we may adopt appropriate treatment to prevent further damages to astronauts during spaceflight.

Keywords: Microgravity, Testosterone, Rat, Aerospace Medicine
Full-Text [PDF 498 kb]   (2476 Downloads)    
Type of Study: Original | Subject: Aerospace Medicine
Received: 2015/12/21 | Accepted: 2016/04/23 | Published: 2016/04/23
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghayumi S, Khoshvaghti A, NurMohammadi A. The effect of microgravity model (hind limb suspension) on the levels of testosterone and LH in rats. EBNESINA 2016; 18 (1) :4-10
URL: http://ebnesina.ajaums.ac.ir/article-1-365-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 18, Issue 1 (spring 2016) Back to browse issues page
ابن سینا EBNESINA
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4645