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Comparison between the effectiveness of glucosamine sulfate and zintoma on clinical improvement of knee osteoarthritis
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M Ramezani   , N Nekozad |
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Abstract: (53579 Views) |
Background: Osteoarthritis is one of the most prevalent human articular diseases, with numerous personal, social and familial problems. This study was conducted to assess the effectiveness of Glucosamine sulfate, Zintoma and Placebo in knee OA clinical improvement.
Materials and methods: Considering inclusion criteria, 225 patients with primary knee• OA were studied in three groups, for 12 weeks, as a double blind placebo controlled randomized clinical trial. all the above mentioned drugs were used by patients for three times a day, and pain parameter (on the base ofVAS-100 mm) and function (on the base of WOMAQ questionnaire) were measured at regular intervals of 0, 6 and 12 week, and then compared by K SQUARE-test.
Results: from all 225 patients 35 were excluded because of the drug: side effects, particularly GI. from the othe, 63 were classified in Zintoma group, 59 in Glucosamine sulfate group, and 68 in Placebo group. based on the findings, pain intensity at the resting time had significant analytic decreased in all groups at 6th week (P=0.001). At the first week, pain intensity showed also significant decreased only in Zintoma and Glucosamine groups sulfate, (P=0.001).The pain reduction rate significant in both groups of Glucosamine sulfate and Zintoma (P=0.02) in contrast to Placebo group (P=0.4). The knee pain on movement was reduced significantly in all three groups at throughout the (P=0.001).
Conclusion: Results of present study indicated that use of Zintoma might be more effective to reduce knee movement pain, compared with the Glucosamine sulfate. All in all it seems that more research is needed to compare the effectiveness of such drugs, especially in a worldwide scale. |
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| Keywords: Knee osteoarthritis, Glucosamine sulfate Ginger powder |
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Full-Text [PDF 163 kb]
(5462 Downloads)
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Type of Study: Original |
Received: 2012/05/22 | Accepted: 2014/06/3 | Published: 2014/06/3
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