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The preventative role of sesame oil on phlebitis induced by anti-neoplastic agents
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N Nekozad *   , T Ashktorab , F Mojab , H Alavi , P Azadeh |
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Abstract: (15337 Views) |
Background: Phlebitis is an inflammatory response to intravenously injected chemotherapy drugs and the reported incidences about 70% among colorectal cancer patients. The purpose of this study was to determine the effect of external use of Sesame Oil (SO) in prevention of chemotherapy-induced phlebitis.
Materials and methods: This randomized controlled clinical trial was performed on 60 patients with colon or rectum cancer, who randomly divided in two equal, control & intervention groups.
This protocol was used 10 drops of SO every 12 hours, two times a day, from the first day of chemotherapy up to the four tenth day, whereas control group received nothing. Data tools included a bipartite questionnaire (demographic Q, clinical Q & Infusion Therapy scale) for measurement of phlebitis.
Results: The incidence of phlebitis in intervention group were significantly lower than that in control group (p<0.05). Kaplan–Meier survival analysis showed that the median survival was Less than4 days in the intervention and 8 days more in the control. In addition, there was statistically significant difference between grade and incidence of chemotherapy-induced phlebitis with SO and control group (p<0.05).
Conclusion: This study shows that external use of SO is effective and well tolerated for prophylaxis from chemotherapy- induced phlebitis. Therefore, it can be suggest as a selected Prevention method for reducing the complication. |
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| Keywords: Sesame Oil, Prophylaxis, Phlebitis, Chemotherapy |
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Full-Text [PDF 196 kb]
(2582 Downloads)
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Type of Study: Original |
Received: 2012/05/23 | Revised: 2012/05/28 | Accepted: 2014/06/3 | Published: 2014/06/3
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