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The effect of chronic constriction injury after a period of endurance training on the expression of TRPC1 and TRPC3 in the plantaris muscle of male Wistar rats
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Abdolreza Kazemi *    , Hadi Kerendi , Parvaneh Dinarzehi , Naimeh Nekoie |
| Department of Sports Science, Faculty of Literature and Humanities, Vali-e-Asr University of Rafsanjan, Rafsanjan, Iran , rkazami22@yahoo.com |
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Abstract: (328 Views) |
Background and aims: Due to the role of TRPC1/3 in muscle atrophy, this study aimed to investigate the effect of Chronic Constriction Injury (CCI) after a period of endurance training on TRPC1/3 gene expression in the plantaris muscle of male Wistar rats.
Methods: Thirty-two rats were randomly divided into four groups of eight each (Control, Control-CCI, Training-CCI, and Training). Finally, the rats were anesthetized, and their plantaris muscle was extracted. Gene expression was measured using Real-Time-PCR.
Results: The findings showed a significant decrease in plantaris muscle weight in the CCI-control group compared to the training groups (Training-CCI and Training) (p=0.001). Additionally, a significant increase in TRPC1 expression was observed in the Training group compared to the control groups (Control and Control-CCI) (p=0.001). Moreover, there was a significant increase in TRPC1 expression in the Training-CCI group compared to the control groups (Control and Control-CCI) (p=0.006). Furthermore, a significant increase in TRPC3 expression was observed in the Training group compared to the other groups (p=0.001), and a significant increase in TRPC3 expression was observed in the Training-CCI group compared to the Control-CCI group (p=0.008).
Conclusion: The results demonstrated a significant difference in the weight of the plantaris muscle, as well as a significant increase in TRPC1/3 expression as a result of endurance training. CCI leads to muscle atrophy and TRPC1/3 dysregulation. Therefore, the history of endurance training can modulate the expression of TRPC1/3 and prevent CCI-induced muscle atrophy.
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| Keywords: Muscle Atrophy, Endurance training, Transient Receptor Potential Channel |
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Full-Text [PDF 1181 kb]
(236 Downloads)
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Type of Study: Original |
Subject:
Aerospace Medicine
Received: 2023/06/18 | Revised: 2024/06/1 | Accepted: 2023/10/31 | Published: 2024/03/7
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