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Response of acute incremental aerobic activity along with electrical stimulation on some markers of angiogenesis in Isoproterenol induced rats
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Mohammad Malekipooya *    |
| Department of Exercise Physiology, Arak Branch, Islamic Azad University, Arak, Iran , Maleki.p@gmail.com |
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Abstract: (459 Views) |
Background and aims: Sports activity is an important and protective factor after cardiovascular diseases. The aim of this study was to investigate the response of acute incremental aerobic activity along with electrical stimulation on some markers of angiogenesis in Isoproterenol (ISO) induced rats.
Methods: This controlled experimental study involved 50 male rats (eight weeks old, weighing 210±15g) subjected to infarction with ISO (150mg/kg), subsequently divided randomly into 5 groups of 10: healthy, infarcted, engaged in sports activity, exposed to electrical stimulation, and engaged in aerobic activity combined with electrical stimulation. The intervention groups underwent activity (at a speed of 10 to 18m/min for 50 minutes) and electrical stimulation (at an intensity of 0.5mA for 20 minutes) in a single session. Venous blood samples were collected and analyzed using the ELISA method, with statistical analysis performed using the ANOVA test at a significance level of p<0.05.
Results: Inducing rats with ISO resulted in a significant elevation in serum levels of VEGF and TSP1 in all groups (p=0.0001 for both). The ANOVA test revealed that a single session of sports activity led to a non-significant increase in VEGF levels and a non-significant decrease in TSP1 levels in infarcted rats in all groups compared to the infarcted group.
Conclusion: Incremental aerobic activity and electrical stimulation demonstrated positive effects on angiogenesis processes. However, due to the lack of statistical significance, further studies are warranted to explore the enhancement and proliferation of new capillary vessels in infarcted samples.
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| Keywords: Aerobic Exercise, Myocardial Infarction, VEGFs, TSP-1 |
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Full-Text [PDF 635 kb]
(214 Downloads)
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Type of Study: Original |
Subject:
Sub-aquatic Medicine
Received: 2023/08/10 | Accepted: 2023/11/6 | Published: 2024/05/26
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