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:: Volume 12, Issue 1 (Spring 2009) ::
EBNESINA 2009, 12(1): 26-31 Back to browse issues page
Effects of Mustard gas and its metabolits Mutagenesis on victims of chemical weapons
F Pour-Esmaeili
Abstract:   (2964 Views)
The two major threat classes of chemical weapons are mustard gas and the nerve agents. Mustard was used in World War I, and there is an extensive human database on it. The fact that mustard gas is a carcinogen and readily produces a variety of chronic or persistent effects was not fully appreciated until after the war and following extensive human occupational exposure prior to World War II. Many of the toxicologic studies and human toxicity estimates for both mustard agents were generated for the purpose of developing chemical agents that would quickly produce maximal casualties in the least sensitive male soldier. We must also consider the effects of chemical agents on civilian populations and the effects of prolonged exposures to relatively low doses. These materials have always been extremely potent and efficacious. Their toxicity has not changed, but our perception of it has. Mustard gas is one of alkylating agents which has been used against soldiers in wars. This hazardous agent has uncopensable effects on humanbeing and other organisms. Mutagenicity, carcinogenicity and teratogenic effects of this toxic gas has been investigated by many scientists, but still there remained unknown facts about mutagenic effects of sulfur mustard and its metabolites to be solved. In this study, to find an easy, quick and efficient test to indicate mutagenicity of sulfur mustard and its metabolites, 20 urine samples were collected from injoured patients who were exposed to mustard gas in Sardasht area. Samples were assayed for the presence of mutagens by Ames and Fluctuation tests using bacteria strains salmonella typhymurium TA98, TA100 and TA102. This study showed that salmonella typhymurium TA102 is the best strain to be used for detection of mutagens in urine samples of patients exposed tro mustard gas. It was clearly shown that fluctuation test was much more sensitive test than Ames test in detecting low doses of mutagen.
Keywords: Mustard Gas, Alkylating agent ns
Full-Text [PDF 271 kb]   (1165 Downloads)    
Type of Study: Research | Subject: General
Received: 2014/09/8 | Accepted: 2014/09/8 | Published: 2014/09/8
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Pour-Esmaeili F. Effects of Mustard gas and its metabolits Mutagenesis on victims of chemical weapons. EBNESINA. 2009; 12 (1) :26-31
URL: http://ebnesina.ajaums.ac.ir/article-1-201-en.html


Volume 12, Issue 1 (Spring 2009) Back to browse issues page
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