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:: Volume 17, Issue 1 (Spring 2015) ::
EBNESINA 2015, 17(1): 4-9 Back to browse issues page
Evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation model
A Khoshvaghti , A NurMohammadi, Shahin Jahani Maleki
Aerospace and Subaquatic Medicine Research Center, AJA University of Medical Sciences, Tehran, Iran , anatomygray2009@gmail.com
Abstract:   (2730 Views)

Background: Bone loss is a well-documented phenomenon occurring in humans both in short- and long-term spaceflights. Revealing data on the role of erythropoietin (EPO) in bone formation has led some to suggest that EPO treatment could also play a role in protecting bone against microgravity-induced bone loss. The aim of the present study was to investigate the effects of EPO administration on densitometric changes of femur of rat in a Microgravity Simulation Model (MSM). Materials and methods: Twelve rats were divided into two groups: the tail-suspended control (TSC), and the tail-suspended group treated with rhEpo (TSE) (300 U/kg every 48 hours). The experiment lasted for 3 weeks. The animals were sacrificed, the right femur of each rat was removed, and bone mineral density was measured for each animal. Results: Bone mineral density of whole femur in TSE group was significantly higher than TSC group (0.160±0.003 vs. 0.144±0.006, p=0.002). Conclusion: According to the results of this study, Erythropoietin administration might have protective effects against microgravity-induced mineral loss in a rat MSM.

Keywords: Osteoporosis, Weightlessness, Bone Mineral Density, Erythropoietin
Full-Text [PDF 1344 kb]   (750 Downloads)    
Type of Study: Original |
Received: 2015/05/31 | Accepted: 2015/09/30 | Published: 2015/09/30
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Khoshvaghti A, NurMohammadi A, Jahani Maleki S. Evaluation the effect of erythropoietin on osteoporosis in a microgravity simulation model. EBNESINA. 2015; 17 (1) :4-9
URL: http://ebnesina.ajaums.ac.ir/article-1-279-en.html

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