A review of antibiotic therapies for odontogenic infections with pulpal origin
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M Derafshi , A Osturiyan |
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Abstract: (10604 Views) |
The dental biofilm is a complex bacterial ecosystem that undergoes
evolution, maturing and development, and thus leads to
odontogenic infections. These infections often follow a chronic
course of evolution. However, if the virulence of pathogenic bacteria
increases and it becomes associated with changes in the host
immune system, it may lead to exacerbation and spreading of
infection to other areas of the body. It's important in treatment of
odontogenic infection that it' s etiologic factor is evaluated at first so
that the infection is limited by mechanical debridement through
surgery and/or antimicrobial therapy. Surgical techniques primarily
have a few effects (by reducing the number of bacteria and the size
of lesion) and if they are used alone, they primarily lead to
improvement of clinical symptoms that in most cases is considered
as therapeutic success mistakenly, but ultimately odontopathogen
may persist and cause chronic infection or infection recurrence.
Therefore, microbiological examinations may be helpful in
introducing of a more reliable treatment method with more precise
prognosis of infection recurrence and also selection of the most
effective antibiotic. Antibacterial drugs are able to change the
bacterial composition of biofilm quantitatively and qualitatively, and
also can penetrate to regions that aren't accessible through
mechanical debridement and can be effective. However, incorrect
selection of antibacterial drugs can lead to form resistant bacterial
species in the biofilm and cause side effects. For decreasing of this
risk and obtaining of maximum effect from these therapeutic drugs,
it's necessary to know the clinical usages of antibacterial drugs and
to aware of the effects of various antibiotics on bacteria that cause
odontogenic infections. |
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Keywords: Dental biofilm, Odontogenic infection, Antibiotic, Dental pulp |
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Full-Text [PDF 297 kb]
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Type of Study: Original |
Received: 2012/03/6 | Accepted: 2014/06/3 | Published: 2014/06/3
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