[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Ethics::
Contact us::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Index






     
 
..
:: Volume 19, Issue 3 (Autumn 2017) ::
EBNESINA 2017, 19(3): 4-12 Back to browse issues page
The effect of exercise training before and after exposure to breast cancer on Bax and Bcl-2 levels on myocardial tissue in female mice
Z Ebrahimpur , M Peeri * , H Matin Homaee , P Farzanegi
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran , zeynab1155@yahoo.com
Abstract:   (4090 Views)

Background: Breast cancer is the most common type of cancer among women. Also, the risk of mortality from cardiovascular diseases in these patients is more than other people. Aerobic exercise is effective in the prevention and treatment of cardiovascular diseases and breast cancer. This study was performed to investigate the effects of swimming exercise before and after of cancer on levels of Bax and Bcl-2 in female mice of myocardium.
Materials and methods: In this study, 56 BALB/c mice were randomly divided into two active and passive groups. The active group swam in the water pool before breast cancer for four weeks, three days per week and 30 minutes daily. Passive group did no exercise before cancer cell inoculation. Then, both groups were separately divided into four subgroups: a) continue to exercise, b) rest, c) doxorubicin, and d) exercise/doxorubicin. Finally, Bax and Bcl-2 levels (as apoptotic markers) in myocardial tissue were measured.
Results: The Results showed that level of Bcl-2 and Bax in myocardial tissue respectively increased and decreased significantly in the group that had aerobic swimming exercise before and after breast cancer in comparison to the group that did not exercise, .
Conclusion: Aerobic swimming exercises before and after the breast cancer is effective on the level of Bax and Bcl-2 in myocardial tissue in mice with breast cancer. Therefore, regular swimming aerobic exercise may increase myocardial cell survival in breast cancer patients.

 

Keywords: Bax protein mouse, bcl-2 Gene, Breast Cancer, Swimming, Myocardium
Full-Text [PDF 577 kb]   (1272 Downloads)    
Type of Study: Original |
Received: 2016/11/12 | Accepted: 2017/10/11 | Published: 2017/10/11
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ebrahimpur Z, peeri M, Matin Homaee H, farzanegi P. The effect of exercise training before and after exposure to breast cancer on Bax and Bcl-2 levels on myocardial tissue in female mice. EBNESINA 2017; 19 (3) :4-12
URL: http://ebnesina.ajaums.ac.ir/article-1-466-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 19, Issue 3 (Autumn 2017) Back to browse issues page
ابن سینا EBNESINA
Persian site map - English site map - Created in 0.06 seconds with 39 queries by YEKTAWEB 4642