Evaluation T-SPOT TB test in diagnosis of tuberculosis
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M Aminiyanfar , M Salehi , A Javanmard |
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Abstract: (14514 Views) |
Background: Tuberculosis (TB) is a chronic infection disease which
more than 50% of untreated patients will die during the period of
five years after diagnosis. The main goal in TB program is early
diagnosis and treatment. Some biochemical tests such as T-SPOT
serologic test could be useful for the rapid diagnosis of tuberculosis.
Materials and Methods: We conducted a cross-sectional study in 60
patients suspected TB which 30 patients were sputum positive and
the remainders were sputum negative for acid fast bacilli. After
entering the data in the SPSS software, results were showed as
specificity, sensitivity, positive and negative predictive value, and
likelihood ratio.
Results: Twenty-three out of 30 patient with sputum positive and 12
patients with sputum negative have positive T-SPOT. The
sensitivity, specificity, positive predictive value, negative predictive
value, likelihood ratio were 76%, 40%, 56%, 63%, 1.25 respectively.
Conclusion: We could not differentiate between active and latent
infection by using this test. Despite the high infectivity of
tuberculosis in this region, this test would not help as a valuable
diagnostic method because of the increased pulmonary infection
other than TB and lower likelihood ratio. |
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Keywords: Tuberculosis, T-SPOT, Sensitivity, Specificity, Serologic tests |
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Type of Study: Original |
Received: 2012/03/7 | Accepted: 2014/06/3 | Published: 2014/06/3
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