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The effect of eight weeks of high-intensity interval training and thyme honey on changes in Pdx1 gene expression in pancreatic tissue and insulin resistance index male rats with type 2 diabetes
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Marzie Mazraekhatiri    , Sajad Arshadi , Abdolali Banaeifar , Hossein Abednatanzi |
| Department of Sport Physiology, South Tehran Branch, Islamic Azad University, Tehran, Iran , arshadi.sajad@yahoo.com |
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Abstract: (1458 Views) |
Background and aims: Diabetes is one of the metabolic disorders that leads to various cardiovascular and metabolic diseases. The aim of this study was to investigate the interactive effect of high-intensity interval training (HIIT) and thyme honey on Pdx1 gene expression and insulin resistance index among type 2 diabetic male rats.
Methods: Totally, 36 rats became diabetic by intraperitoneal injection of strepotozocin after 20 weeks of high-fat diet. The rats were divided into four groups: control, HIIT, honey, HIIT+honey. Eight weeks of HIIT, five sessions per week was performed. Thyme honey at a dose of 3g/Kg/day was gavaged. Glucose, insulin, insulin resistance index, and Pdx1 gene expression were measured. Data were analyzed by one-way ANOVA and post hoc Bonferroni’s tests.
Results: Our results showed that glucose and insulin resistance index decreased in the HIIT+honey group compared to the control group (p=0.001). There was a significant increase in insulin (p=0.001) and a significant decrease in Pdx1 gene expression (p=0.0001) in all experimental groups compared to the control group.
Conclusion: HIIT and thyme honey had an effect on reducing glucose and insulin resistance index. In addition, HIIT and honey reduced the expression of Pdx1 gene in pancreatic tissue.
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| Keywords: Honey, High Intensity Interval Training, Insulin Resistance, pancreatic and duodenal homeobox gene-1 |
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Full-Text [PDF 1231 kb]
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Type of Study: Original |
Received: 2021/05/26 | Accepted: 2021/08/31 | Published: 2022/03/30
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